Endocrine Abstracts

Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis drugs induced are a rare side effect of antithyroid drugs. It is more commonly associated with propylthiouracil (PTU). The clinical manifestations are polymorphic like in primary vasculitides, but less severe; ranging from less specifics syndromes to multiple organs injured and lifethreatening in rare case. Cardiac involvement is uncommon. Herby we present the first case report of a 25-yr-old wom...

Introduction: Antiphospholipid syndrome (APS) is an acquired thrombotic disorder. It mainly occurs with systemic disease or as a primary disorder. All organs may be involved by thrombosis. But endocrine disorders seen in antiphospholipid syndrome are rare. In the literature, rare cases of hypopituitarism with APS have been reported.The observation: It is a 27 years old patient who consults for headache with diplopia. The interview underlines galactorrhea...

Introduction: The obstructive sleep apnea syndrome (OSAS) has a well-documented association with increase cardiovascular morbidity and mortality. The patients with OSAS have a high prevalence of hypertension (HTA).Case report: A 52-year-old female with a history of poorly controlled resistant HTA was admitted to our hospital with severe HTA. She had a history of fatigue and intermittent episodes of palpitations. Laboratory evaluation was significant for ...

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in type 2 diabetes patients over 65 years age.Methods: The age of the participants were between 60 and 87 years old. According to NCEP ATP III criteria 30 had MS and 28 had not. Cognitive performance was determined with the use of standardised mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated th...

Introduction: Empty sella in male patients is a very rare situation. It could be diagnosis in acquired male hypogonadotropic hypogonadism or hypopituitarism.Case report: A 55-year-old type 2 diabetes male was referred to our hospital with erectile dysfunction (ED). He has three children. His secondary sex characteristics, sexual function, and ejaculation were previously normal but for the last 3 years he had ED. His genital stage was Tanner V, and pubic ...

Introduction: Hyperthyroidism produce changes in cardiac contractility, blood pressure, and systemic or pulmonary vascular resistance. In almost all cases these cardiovascular changes are reversible when the underlying thyroid disorder is recognised and treated. Pulmonary hypertension (PAH) has been associated with thyroid dysfunction, but primarily with hyperthyroidism. The vast majority of patients with this form of PAH are usually older with toxic multinodular goitre. The a...

Introduction: A 66-year-old woman was admitted as an emergency with vomiting, hypotension and serum cortisol of 0.92 microg/dl indicative of adrenal failure. She was found to be hyperthyroid (fT4=72 pmol/l).Case report: She had hypotension (blood pressure 80/40 mm/Hg) She was fit and well till the age of 65. Endocrine assessment revealed deficiency in ACTH-cortisol, growth hormone, and gonadotropin, as well as low-normal fT4. On the...

Introduction: Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the foetus.Case presentation: We report a case of hyperthyroidism in a 28-year-old woman that occurred at 20 weeks gestation. This situation was due to Graves’ disease. Propylthiouraci...

Introduction: Pheochromocytoma is a functional catecholamine producing tumor that originates from adrenal chromaffin cells and is an extremely rare cause of ectopic Cushing syndrome. We report clinical case of adrenal incidentaloma with the evidence of both pheochromocytoma and sub-clinical Cushing’s syndrome.Observation: A fifty-two year-old female patient was referred to our institution because of an incidentally discovered right adrenal mass. Al...

Introduction: Testosterone levels are frequently low in men with type two diabetes mellitus, and sexual symptoms are a prominent presenting feature for these men.Objectives: The aim of this study was to determine the frequency of hypogonadism and related risk factors among Tunisian patients with type two diabetes mellitus and erectile dysfunction.Methods: This cross–sectional study included a total of one hundred and thirty c...